Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical
Solaraze gel contains the active ingredient diclofenac sodium, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). The gel is used to treat a skin condition called actinic keratosis.
Actinic keratoses are rough areas of skin caused by sun damage over many years, eg from sunbathing or using sunbeds, or working outdoors. They occur in fair-skinned people, whose skin is particularly sensitive to the damaging effect of UV rays.
The skin lesions are usually harmless, however about two percent will turn into a skin cancer (squamous cell carcinoma). Some small actinic keratoses may disappear on their own. However, the chance of an actinic keratosis turning into a skin cancer falls if the actinic keratosis is treated early.
Is not fully understood how diclofenac works in treating actinic keratoses. Diclofenac’s action in the body involves inhibiting a substance called cyclo-oxygenase. This is normally involved in the production of various chemicals in the body, some of which are known as prostaglandins. By inhibiting the action of cyclo-oxygenase diclofenac reduces the production of prostaglandins. It is thought that Solaraze gel may work by reducing the production of a particular type of prostaglandin called PGE2.